C-telopeptide, and osteocalcin levels in healthy rats

It is still not completely clear whether carbamazepine causes alterations in vitamin D status and in bone metabolism. Th e objective of this study was to investigate the eff ects of carbamazepine on serum levels of -hydroxyvitamin D and on biomarkers of bone formation and resorption in healthy rats. Levels of calcium, hydroxyvitamin D, parathormone, C-telopeptide, bone specifi c alkaline phosphatase and osteocalcin were measured in  groups of rats consisting of controls (n=), isotonic saline solution group (n=) and carbamazepine group (n=). Mean calcium levels were found to be signifi cantly lower in healthy controls in comparison to isotonic saline solution and carbamazepine groups (.±., .±., .±. mg/dL, respectively, p<.). Mean levels of hydroxyvitamin D, were found to be signifi cantly higher in control group compared to isotonic saline solution group (hydroxyvitamin D; .±., .±. ng/mL, respectively, p<.). Mean levels of parathormone and osteocalcin were found to be signifi cantly higher in control group compared to isotonic saline solution group and carbamazepine group. Parathormone levels were measured as .±., .±., .±. pg/mL, respectively (p<.). Osteocalcine levels were measured as .±., .±., .±. ng/mL, respectively (p<.). A signifi cant diff erence in terms of mean serum bone specifi c alkaline phosphatase and C-telopeptide levels among groups was not observed. Th e main outcome of this prospective study in healthy rats showed no change in biochemical parameters of bone turnover during treatment with carbamazepine. ©  Association of Basic Medical Sciences of FBIH. All rights reserved